Epidemiology: associated with use of dextran during hysteroscopy
Hyskon is a low molecular weight dextran used mainly in hysteroscopic surgery (usually to treat infertility): endometrial cavity is usually distended with 500 mL of low molecular weight dextran
Risk Factors for Acute Lung Injury from Dextran Use During Hysteroscopy
Use of >500 mL Dextran
Excessive Irritation of Endometrial Surface
Procedure Length >45 min
Diffuse Alveolar Hemorrhage (DAH) (see Diffuse Alveolar Hemorrhage, [[Diffuse Alveolar Hemorrhage]]): absence of pulmonary capillaritis
Hematologic Adverse Effects
Acquired Von Willebrand Disease (see Von Willebrand Disease, [[Von Willebrand Disease]]): branched polysaccharides of 40 or 70 kDa which inhibit platelet factor-3 availability, adsorb to platelets, and decrease plasma factor VIII-VWF -> inhibit platelet aggregation + secretion
