Dantrolene
Indications
Pharmacology
- Long-Acting Skeletal Muscle Relaxant: contains a hydantoin moiety
- Inhibits release of calcium from muscle sarcoplasmic reticulum and antagonizes calcium effect on muscle contraction
Administration
- IV: 2.5 mg/kg, repeat q5 min to max 10 mg/kg or until improvement, then maintenance q 5-8 hrs
Adverse Effects
Pulmonary Adverse Effects
- Pleural Effusion (see Pleural Effusion-Exudate, [[Pleural Effusion-Exudate]])
- Diagnosis
- CBC: eosinophilia
- Pleural Fluid: may have pleural eosinophilia
Cardiac Adverse Effects
Other Adverse Effects
References