Clopidogrel (Plavix)
Pharmacology
- PO: 75 mg qday
- Mechanism: irreversibly inhibits platelet surface ADP receptor -> IIb/IIIa inhibition (IIb/IIIa normally acts as receptor for fibrinogen, vitronectin, fibronectin, and vWF) -> prevents cross-linking of platelets by fibrin -> inhibits platelet aggregation
Adverse Effects
References
- Diffuse Alveolar Hemorrhage After Clopidogrel Use. J Invasive Cardiol. 2001;13(7)