Indications

• Bladder Cancer (see Bladder Cancer, [[Bladder Cancer]])
• Breast Cancer (see Breast Cancer, [[Breast Cancer]])
• Cervical Cancer (see Cervical Cancer, [[Cervical Cancer]])
• Endometrial Carcinoma (see Uterine Cancer, [[Uterine Cancer]])
• Esophageal Cancer (see Esophageal Cancer, [[Esophageal Cancer]])
• Gastric Cancer (see Gastric Cancer, [[Gastric Cancer]])
• Head and Neck Cancer (see Head and Neck Cancer, [[Head and Neck Cancer]]))
• Hodgkin’s Disease (see Hodgkin’s Disease, [[Hodgkins Disease]])
• Lymphoma (see Lymphoma, [[Lymphoma]])
• Non-Small Cell Lung Cancer (see Lung Cancer, [[Lung Cancer]])
• Osteosarcoma
• Penile Cancer
• Pleural Mesothelioma (see Mesothelioma, [[Mesothelioma]])
• Ovarian Cancer (see Ovarian Cancer, [[Ovarian Cancer]])
• Small Cell Lung Cancer (see Lung Cancer, [[Lung Cancer]])
• Testicular Cancer (see Testicular Cancer, [[Testicular Cancer]])

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Contraindications

• Chronic Kidney Disease (CKD) (see Chronic Kidney Disease, [[Chronic Kidney Disease]])

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Pharmacology

• Platinum-Based Agent Which Inhibits DNA Synthesis
  • Formation of DNA Crosslinks: may also form intra-strand crosslinks
  • Denaturation of DNA Double Helix
  • Covalent Binding to DNA Bases: disrupts DNA function
  • Possible Binding to DNA Proteins

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Administration

• IV:

Dose Adjustment

• Hepatic
• Renal

Extravasation Management

• General Management
  • Elevated Arm
  • Gently Aspirate Extravasated Solution : do not flush the line
• Sodium Thiosulfate
• Dimethyl Sulfoxide (DMSO)

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Adverse Effects

Allergic/Immunologic Adverse Effects

• Anaphylaxis (see Anaphylaxis, [[Anaphylaxis]])

Gastrointestinal Manifestations

• Elevated Liver Function Tests (LFT’s) (see xxxx, [[xxxx]])
• Nausea/Vomiting (see Nausea and Vomiting, [[Nausea and Vomiting]]): common

Hematologic Manifestations

• Myelosuppression: this is a major dose-related toxicity of cisplatin
  • Anemia (see xxxx, [[xxxx]])
  • Leukopenia/Neutropenia (see xxxx, [[xxxx]])
  • Thrombocytopenia (see xxxx, [[xxxx]])
• Hemolytic Anemia (see Hemolytic Anemia, [[Hemolytic Anemia]])

Neurologic Adverse Effects

• Hiccups (see Hiccups, [[Hiccups]])
• Optic Neuritis
• Ototoxicity
• Peripheral Neuropathy (see Peripheral Neuropathy, [[Peripheral Neuropathy]])
• Posterior Reversible Encephalopathy Syndrome (PRES) (see Posterior Reversible Encephalopathy Syndrome, [[Posterior Reversible Encephalopathy Syndrome]])
• Retinopathy
• Vestibulopathy

Renal Adverse Effects

• Acute Kidney Injury (AKI) (see Acute Kidney Injury, [[Acute Kidney Injury]])

Other Manifestations

• xxx
• xxx
• xxx

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References

• xxx