Epidemiology

• Indications
  • Neuroendocrine Tumors

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Pharmacology

• Nitrosurea

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Adverse Effects

Pulmonary

• Acute Pneumonitis (see Pneumonia)
  • Treatment/Prognosis: responds to drug withdrawal and corticosteroids
• Interstitial Pulmonary Fibrosis (see Interstitial Lung Disease-Etiology)
• Pneumothorax (see Pneumothorax)

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References

• Chlorozotocin (DCNU)–induced pulmonary toxicity. Cancer Clin Trials. 1981 Winter;4(4):397-9
• Combination chemotherapy pneumonitis: a case report of possible synergistic toxicity. Med Pediatr Oncol 1983; 11: 116-118
• Pulmonary disease as a complication of chlorozotocin chemotherapy. Cancer Treat Rep 1981; 65: 223-229