Ulcerative Colitis (UC) (see Ulcerative Colitis, [[Ulcerative Colitis]])
Pharmacology
PEGylated Fab Fragment of a Humanized TNF-α Inhibitor Monoclonal Antibody (see Anti-Tumor Necrosis Factor-α Therapy, [[Anti-Tumor Necrosis Factor-α Therapy]])
Metabolism
xxx
Administration
SQ
Dose Adjustment
Hepatic: xxx
Renal: xxx
Adverse Effects
Infectious Adverse Effects of Anti-Tumor Necrosis Factor-α (Anti-TNFα) Therapy
Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes. Nature 1993; 364:798-802
Etanercept therapy in rheumatoid arthritis: a randomized, controlled trial. Ann Intern Med 1999; 130:478-486
Infliximab (chimeric anti-tumor necrosis factor-alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial. Lancet 1999; 354:1932-1939
Tumor necrosis factor alpha antibody (infliximab) therapy profoundly downregulates the inflammation in Crohn’s ileocolitis. Gastroenterology 1999; 116:22-28
Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent. N Engl J Med 2001; 345:1098-1104
Cell-mediated immunity to Histoplasma capsulatum. Semin Respir Infect 2001; 16:102-108
Life-threatening histoplasmosis complicating immunotherapy with tumor necrosis factor-alpha
antagonists infliximab and etanercept. Arthritis Rheum 2002; 46:2565-2570
Methotrexate pneumonitis after initiation of infliximab therapy for rheumatoid arthritis. Arthritis Rheum 2002; 47:670-671
Delayed hypersensitivity reaction and acute respiratory distress syndrome following infliximab infusion. Inflamm Bowel Dis 2002; 8:186-191 [MEDLINE]
Accelerated nodulosis and vasculitis following etanercept therapy for rheumatoid arthritis. Arthritis Rheum 2002; 47:445-449 [MEDLINE]
Methotrexate pneumonitis after initiation of infliximab therapy for rheumatoid arthritis. Arthritis Rheum 2002; 47:670-671
Treatment of active ankylosing spondylitis with infliximab: a randomised controlled multicentre trial. Lancet 2002; 359:1187-1193
Frequency of infection in patients with rheumatoid arthritis compared with controls: a population-based study. Arthritis Rheum 2002; 46:2287-2293
Accelerated nodulosis and vasculitis following etanercept therapy for rheumatoid arthritis. Arthritis Rheum 2002; 47:445-449
Treatment of active ankylosing spondylitis with infliximab: a randomised controlled multicentre trial. Lancet 2002; 359:1187-1193
Delayed hypersensitivity reaction and acute respiratory distress syndrome following infliximab infusion. Inflamm Bowel Dis 2002; 8:186-191
Anti-tumour necrosis factor agents and tuberculosis risk: mechanisms of action and clinical management. Lancet Infect Dis 2003; 3:148-155
Tuberculosis in the cytokine era: what rheumatologists need to know. Arthritis Rheum 2003; 48:2085-2091
Histoplasmosis after treatment with anti-tumor necrosis factor-alpha therapy. Am J Respir Crit Care Med 2003; 167:1279-1282
Granulomatous infections and tumor necrosis factor-antagonist therapies. Abstract (# THU0209) presented at: Proceedings of the Annual European Congress of Rheumatology European League Against Rheumatism; June 18-21, 2003; Lisbon, Portugal.
Listeria monocytogenes infection as a complication of treatment with tumor necrosis factor alpha- neutralizing agents. Arthritis Rheum 2003; 48:319-324
Increased risk of coccidioidomycosis in patients treated with tumor necrosis factor-alpha antagonists. Arthritis Rheum 2004; 50:1959-1966
Tumor necrosis factor-alpha blockade for the treatment of acute GVHD. Blood 2004; 104:649-654
Fatal exacerbation of rheumatoid arthritis associated fibrosing alveolitis in patients given infliximab. BMJ 2004; 329:1266
New drugs for rheumatoid arthritis. N Engl J Med 2004; 350:2167-2179
Effects of infliximab on apoptosis and reverse signaling of monocytes from healthy individuals and patients with Crohn’s disease. Inflamm Bowel Dis 2004; 10:801-810
Pneumocystis carinii pneumonia with oral candidiasis after infliximab therapy for Crohn’s disease. Dig Dis Sci 2004; 1458- 1460
Fatal exacerbation of rheumatoid arthritis associated fibrosing alveolitis in patients given infliximab. BMJ 2004; 329:1266
Interstitial pneumonitis associated with infliximab therapy. J Rheumatol 2006; 33:1189-1193
Pulmonary lymphohistiocytic reactions temporally related to etanercept therapy. Mod Pathol 2005; 18:651-655
Clinical pharmacokinetics of TNF antagonists: how do they differ? Semin Arthritis Rheum 2005; 34:12-18
Tuberculosis associated with therapy against tumor necrosis factor-alpha. Arthritis Rheum 2005; 52:2968- 2974
Infections associated with tumor necrosis factor-alpha antagonists. Medicine 2005; 84:291-302
Pulmonary lymphohistiocytic reactions temporally related to etanercept therapy. Mod Pathol 2005; 18:651-655
Pulmonary complications of infliximab therapy in patients with rheumatoid arthritis. J Rheumatol 2006; 33:622-628
Safety analyses of adalimumab (HUMIRA) in global clinical trials and US postmarketing surveillance of patients with rheumatoid arthritis. Ann Rheum Dis 2006; 65:889-894
Emergence of Legionella pneumophila pneumonia in patients receiving tumor necrosis factor- alpha antagonists. Clin Infect Dis 2006; 43:e95-e100
Pulmonary complications of infliximab therapy in patients with rheumatoid arthritis. J Rheumatol 2006; 33:622-628
Interstitial pneumonitis associated with infliximab therapy. J Rheumatol 2006; 33:1189-1193
Development of active tuberculosis following initiation of infliximab despite appropriate prophylaxis. Rheumatology (Oxford) 2007; 46:887-888
Pneumocystis jiroveci (carinii) pneumonia after infliximab therapy: a review of 84 cases. Dig Dis Sci 2007; 52:1481-1484
Pneumocystis carinii pneumonia in a patient on etanercept for psoriatic arthritis. Ir J Med Sci 2007; 176:309-311
Pneumocystis carinii pneumonia in a rheumatoid arthritis patient treated with adalimumab. Scand J Infect Dis 2007; 39:475-478
Strongyloides stercoralis hyperinfection in a patient with rheumatoid arthritis after anti-TNF-alpha therapy. J Clin Rheumatol 2007; 13:150-152
Acute interstitial nephritis associated with etanercept. Rheumatol Int 2008;28:1283-4
Rheumatology (Oxford). 2009 Jul;48(7):716-20. Epub 2009 May 4
Adalimumab-induced interstitial pneumonia with an improvement of pre-existing rheumatoid arthritis-associated lung involvement. Intern Med. 2011;50(7):749-51