MD Nexus
History and Physical Examination
Calcitriol (1,25-dihydroxycholecalciferol, 1,25-dihydroxyvitamin D3, Rocaltrol)
Indications
Chronic Kidney Disease (CKD) with Renal Osteodystrophy
(see
Chronic Kidney Disease
, [[Chronic Kidney Disease]])
Pharmacology
Synthetic Vitamin D Analog, Which is the Hormonally Active Form of Vitamin D
(see
Vitamin D
, [[Vitamin D]])
Calcitriol increases absorption of dietary calcium from the gastrointestinal tract -> increased serum calcium
Calcitriol increasing renal tubular reabsorption of calcium -> increased serum calcium
Calcitriol increases release of calcium from bone by its action on osteoblasts, causing them to release RANKL -> activation of osteoclasts -> increased serum calcium
Adverse Effects
Hypercalcemia
(see
Hypercalcemia
, [[Hypercalcemia]])
References
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