Inhibition of Sodium-Potassium-Chloride Cotransport in the Ascending Loop of Henle (with Minor Effect on the Proximal Tubule), Resulting in Natriuresis (Equal to Approximately 20% of the Filtered Load of Sodium), Calciuria, Phosphaturia, and Minimal Bicarbonaturia
Bumetanide is Approximately 40x More Potent than Furosemide (in Patients with Normal Renal Function)
Half-Life: 1.2-1.5 hrs
Administration
PO:
IV: 0.5-1 mg q8-12hrs
Dose Equivalence to Furosemide (see Furosemide): 1 mg Bumetanide IV = 40 mg Furosemide IV