Indications

Allergic Asthma (see Asthma, [[Asthma]])

• Clinical Efficacy
  • Systematic Review (88 Trials) of Injection Allergen Immunotherapy in Asthma (Cochrane Database Syst Rev, 2010) [MEDLINE]
    • Trials Used Multiple Allergens: House Dust Mites, Pollen, Animal Dander, Cladosporium Mold, and Latex
    • Allergen Immunotherapy Decreased Asthma Symptoms, Medication Use, and Airway Reactivity
    • Allergen Immunotherapy Had No Consistent Effect on Lung Function
    • Local or Systemic Adverse Effects (Anaphylaxis) Were Observed in Trials

Allergic Rhinitis (see Allergic Rhinitis, [[Allergic Rhinitis]])

• Clinical Efficacy
  • Systematic Review of Sublingual Allergen Immunotherapy in Children and Adults (Allergy, 2011) [MEDLINE]
    • Sublingual Allergen Immunotherapy is Effective
    • No Episodes of Anaphylaxis Were Noted

Food Allergy (see Food Allergy, [[Food Allergy]])

• Clinical Efficacy
  • xxxx
• Recommendations: xxxx

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Pharmacology

• xxx

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Adverse Effects

Allergic Adverse Effects

• Anaphylaxis (see Anaphylaxis, [[Anaphylaxis]])
  • Epidemiology: associated with subcutaneous allergen immunotherapy

Dermatologic Adverse Effects

• Local Skin Site Reaction
  • Epidemiology: associated with subcutaneous allergen immunotherapy

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References

• Injection allergen immunotherapy for asthma. Cochrane Database Syst Rev. 2010 Aug 4;(8):CD001186. doi: 10.1002/14651858.CD001186.pub2 [MEDLINE]
• Systematic reviews of sublingual immunotherapy (SLIT). Allergy. 2011;66(6):740 [MEDLINE]