Indications
Pharmacology
Administration
Dose Adjustment
Adverse Effects
Cardiovascular Adverse Effects
Dermatologic Adverse Effects
Gastroenterologic Adverse Effects
- Elevated Liver Function Tests/Hepatitis (see xxxx, [[xxxx]])
Neurologic Adverse Effects (Neurotoxicity)
- Time of Onset: usually develops early during course of treatment
- Mechanism: probably related to high serum concentrations of acyclovir
- Risk Factors for Neurotoxicity
- Advanced Age
- Bone Marrow Transplantation
- Renal Failure
- Neurologic Adverse Effects
- Ataxia (see Ataxia, [[Ataxia]])
- Coma (see Obtundation-Coma, [[Obtundation-Coma]])
- Delirium (see Delirium, [[Delirium]])
- Dizziness (see Dizziness, [[Dizziness]])
- Focal Neurologic Signs (see Acute Motor Deficit, [[Acute Motor Deficit]])
- Guillain-Barre Syndrome (see Guillain-Barre Syndrome, [[Guillain-Barre Syndrome]]): case report in at least one patient receiving acyclovir prophylaxis after allogeneic bone marrow transplant
- Myoclonus (see Myoclonus, [[Myoclonus]])
- Parasthesias (see Parasthesias, [[Parasthesias]])
- Psychosis (see Psychosis, [[Psychosis]])
- Seizures (see Seizures, [[Seizures]])
Renal Adverse Effects
- Acute Kidney Injury (AKI) (see Acute Kidney Injury, [[Acute Kidney Injury]]): due to intratubular deposition and obstruction
Other Adverse Effects
References