Abemaciclib (Verzenio, Verzenios, Ramiven, Zenlistik)


Breast Cancer (see Breast Cancer)

  • xxx


  • xxx


  • xxx


  • xxx

Dose Adjustment

  • Hepatic: xxx
  • Renal: xxx

Use in Pregnancy (see Pregnancy)

  • xxx

Use During Breast Feeding

  • xxx

Adverse Effects

Pulmonary Adverse Effects

Pneumonitis/Interstitial Lung Disease (ILD) (see Pneumonia and Interstitial Lung Disease)

  • Epidemiology
    • Reports of Interstitial Lung Disease from Japanese Adverse Drug Event Report (JADER) Database and FDA Adverse Event Reporting System (FAERS) (Cancer Rep-Hoboken, 2021) [MEDLINE]
      • Treatment with Abemaciclib and Palbociclib were Associated with a Potential Complication of Interstitial Lung Disease (Regardless of Age)


  • Can CDK4/6 inhibitors cause fatal lung injury? Expert Rev Anticancer Ther. 2019 Nov;19(11):917-919. doi: 10.1080/14737140.2019.1674651 [MEDLINE]
  • New Drugs, Old Toxicities: Pneumonitis Related to Palbociclib – A Case Report. Breast Care (Basel). 2020 Oct;15(5):548-552. doi: 10.1159/000504618 [MEDLINE]
  • CDK 4/6 inhibitor induced lung injury: a case report and review of literature. Ecancermedicalscience. 2021 Jun 7;15:1245. doi: 10.3332/ecancer.2021.1245. eCollection 2021 [MEDLINE]
  • Evaluation of potential complication of interstitial lung disease with abemaciclib and palbociclib treatments. Cancer Rep (Hoboken). 2021 May 3;e1402. doi: 10.1002/cnr2.1402 [MEDLINE]