Agents
- 4-NEMD
- 7-Me-Marsanidine (also I1 agonist)
- Agmatine (also I agonist, NMDA, 5-HT3, nicotinic antagonist and NOS inhibitor)
- Apraclonidine
- Brimonidine
- Cannabigerol (also acts as a moderate affinity 5-HT1A receptor agonist, and low affinity CB1 receptor antagonist)
- Clonidine (Catapres, Kapvay, Nexiclon) (see Clonidine)
- Detomidine
- Dexmedetomidine (Precedex) (see Dexmedetomidine)
- Epinephrine (see Epinephrine): lesser affinity for α2-adrenergic receptor than norepinephrine
- Fadolmidine
- Guanabenz
- Guanfacine
- Lofexidine
- Marsanidine
- Medetomidine
- Methamphetamine
- Mivazerol
- Norepinephrine (Levophed) (see Norepinephrine): greater affinity for α2-adrenergic receptor than epinephrine
- Rilmenidine (also I agonist)
- Romifidine
- Talipexole (also dopamine agonist)
- Tizanidine (Zanaflex) (see Tizanidine): centrally acting
- Tolonidine
- Xylazine
- Xylometazoline
Pharmacology
α2A-Adrenergic Receptor is Found in the Following Central Nervous System Regions
Brainstem (especially the locus coeruleus) Midbrain Hypothalamus Hippocampus Spinal cord Cerebral cortex Cerebellum Septum
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α2B-Adrenergic Receptor is Found in the Following Central Nervous System Regions
Olfactory system Thalamus Pyramidal layer of the hippocampus Cerebellar purkinje layer
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α2C-Adrenergic Receptor is Found in the Following Central Nervous System Regions
Midbrain Thalamus Amygdala Dorsal root ganglia Olfactory system Hippocampus Cerebral cortex Basal ganglia Substantia nigra Ventral tegmentum
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References
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