Middle East Respiratory Syndrome Coronavirus (MERS-CoV)


Clinical Risk Factors (Ann Intern Med, 2014) [MEDLINE]

  • Cardiovascular Disease
    • Cardiac Surgery: present in 25% of cases
    • Congestive Heart Failure (CHF) (see Congestive Heart Failure, [[Congestive Heart Failure]]): present in 17% of cases
    • Hypertension (see Hypertension, [[Hypertension]]): present in 50% of cases
    • Myocardial Infarction: present in 33% of cases
    • Valvular Disease: present in 8% of cases
  • Diabetes Mellitus (DM) (see Diabetes Mellitus, [[Diabetes Mellitus]]): present in 67% of cases
  • Pulmonary Disease
    • Asthma (see Asthma, [[Asthma]]): present in 8% of cases
  • Renal Disease
    • Chronic Kidney Disease (CKD) (see Chronic Kidney Disease, [[Chronic Kidney Disease]]): present in 42% of cases
  • Vascular Disease
  • Other
    • Melanoma (see Melanoma, [[Melanoma]]): present in 8% of cases
    • Neuromuscular Disease: present in 8% of cases
    • Obesity (see Obesity, [[Obesity]]): present in 25% of cases
    • Renal/Liver Transplant (see Renal Transplant, [[Renal Transplant]] and Liver Transplant, [[Liver Transplant]]): present in 8% of cases




Arterial Blood Gas (ABG) (see Arterial Blood Gas, [[Arterial Blood Gas]])

Chest X-Ray (see Chest X-Ray, [[Chest X-Ray]])

Chest CT (see Chest Computed Tomography, [[Chest Computed Tomography]])

Lower Respiratory Tract Specimen MERS-CoV Real-Time Reverse Transcriptase Polymerase Chain Reaction (rRT-PCR)

  • Samples
    • Bronchoalveolar Lavage (BAL) Fluid (see Bronchoscopy, [[Bronchoscopy]])
    • Endotracheal Aspirate
    • Sputum
  • Recommended as First Line Testing by the CDC

Upper Respiratory Tract Specimen

Acute and Convalescent Paired Serum Samples

Stool Sample

Blood MERS-CoV Polymerase Chain Reaction (PCR)

Clinical Manifestations

General Comments

Cardiovascular Manifestations

Gastrointestinal Manifestations

Neurologic Manifestations

Otolaryngologic Manifestations

Pulmonary Manifestations

Renal Manifestations

Rheumatologic Manifestations

Other Manifestations


Supportive Care

Ribavirin and Interferon-Beta (see Ribavirin, [[Ribavirin]] and xxxx, [[xxxx]])

Inhaled Nitric Oxide (iNO) (see Nitric Oxide, [[Nitric Oxide]])