Epidemiology

• xxx

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Microbiology

• Member of Family Enterobacteriaceae (see Enterobacteriaceae, [[Enterobacteriaceae]])
  • Member of Klebsiella Genus (see Klebsiella, [[Klebsiella]])
• Lactose-Fermenting Gram-Negative Rod

Carbapenem-Resistant Enterobacteriaceae (CRE)

• Incidence: 2.93 cases/100k population [MEDLINE]
• Organisms [MEDLINE]
  • Carbapenem-Resistant (Excluding Ertapenem)/Extended-Spectrum Cephalosporin-Resistant Escherichia Coli (see Escherichia Coli, [[Escherichia Coli]])
  • Carbapenem-Resistant (Excluding Ertapenem)/Extended-Spectrum Cephalosporin-Resistant Enterobacter Aerogenes (see Enterobacter Aerogenes, [[Enterobacter Aerogenes]])
  • Carbapenem-Resistant (Excluding Ertapenem)/Extended-Spectrum Cephalosporin-Resistant Enterobacter Cloacae Complex (see Enterobacter Cloacae, [[Enterobacter Cloacae]])
  • Carbapenem-Resistant (Excluding Ertapenem)/Extended-Spectrum Cephalosporin-Resistant Klebsiella Pneumoniae (see Klebsiella Pneumoniae, [[Klebsiella Pneumoniae]])
  • Carbapenem-Resistant (Excluding Ertapenem)/Extended-Spectrum Cephalosporin-Resistant Klebsiella Oxytoca (see Klebsiella Oxytoca, [[Klebsiella Oxytoca]])*
• Clinical Associations
  • Most CRE’s were isolated from a urinary source
  • Most CRE’s were associated with high prevalence of prior hospitalizations, prior indwelling devices, or discharge to a long-term care setting

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Diagnosis

• Sputum Gram Stain and Culture

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Clinical Mainfestations

Otolaryngologic Manifestations

• Acute Hospital-Acquired Bacterial Rhinosinusitis (see Acute Rhinosinusitis, [[Acute Rhinosinusitis]])

Pulmonary Manifestations

• Pneumonia (see Pneumonia, [[Pneumonia]])

Other Manifestations

• xxxxx
• xxxxx

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Treatment

• Carbapenem-Resistant Enterobacteriaceae (CRE): Carbapenem-resistant Klebsiella Pneumoniae
  • xxxx

Acute Skin/Skin Structure Infection

• Ceftaroline (Teflaro, Zinfloro) (see Ceftaroline, [[Ceftaroline]])

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References

• Epidemiology of Carbapenem-Resistant Enterobacteriaceae in 7 US Communities, 2012-2013. JAMA. 2015 Oct 5:1479-1487. doi: 10.1001/jama.2015.12480 [MEDLINE]