Thrombotic Thrombocytopenic Purpura-Acquired (Acquired TTP)



Background-Von Willebrand Factor (vWF)

Background-ADAMTS13 (see ADAMTS13 Activity, [[ADAMTS13 Activity]])

Acquired Thrombotic Thrombocytopenic Purpura is a Thrombotic Microangiopathy Caused by Decreased Activity of ADAMTS13 (Due to an Acquired Autoantibody Inhibitor of ADAMTS13) (see Thrombotic Microangiopathy, [[Thrombotic Microangiopathy]])


Complete Blood Count (CBC) (see Complete Blood Count, [[Complete Blood Count]])

Serum Chemistry (see Serum Chemistry, [[Serum Chemistry]])

Prothrombin Time (PT)/International Normalized Ratio (INR) and Partial Thromboplastin Time (PTT) (see Prothrombin Time, [[Prothrombin Time]] and Partial Thromboplastin Time, [[Partial Thromboplastin Time]])

Serum Lactate Dehydrogenase (LDH) (see Serum Lactate Dehydrogenase, [[Serum Lactate Dehydrogenase]])

Serum Haptoglobin (see Serum Haptoglobin, [[Serum Haptoglobin]])

Reticulocyte Count (see Reticulocyte Count, [[Reticulocyte Count]])

Direct Coombs Test (Direct Anti-Globulin Test) (see Direct Coombs Test, [[Direct Coombs Test]])

Indirect Coombs Test (Indirect Anti-Globulin Test)

Peripheral Blood Smear (see Peripheral Blood Smear, [[Peripheral Blood Smear]])

Urinalysis (see Urinalysis, [[Urinalysis]])

Urine Hemosiderin (see Urine Hemosiderin)

ADAMTS13 Activity (see ADAMTS13 Activity)

Anti-ADAMTS13 Antibodies

Tissue Biopsy

Genetic Testing for ADAMTS13 Gene Mutations

Clinical Differentiation of Hemolytic Syndromes

Clinical Differentiation of Intravascular Hemolysis Syndromes

Clinical Manifestations

General Comments

Cardiovascular Manifestations

Chest Pain with Elevated Serum Troponin (see Chest Pain, [[Chest Pain]] and Serum Troponin, [[Serum Troponin]])

Other Less Common Cardiovascular Manifestations

Dermatologic Manifestations

Petechiae (see Petechiae, [[Petechiae]])

Purpura (see Purpura, [[Purpura]]): common

Gastrointestinal Manifestations

General Comments

Acute Pancreatitis (see Acute Pancreatitis, [[Acute Pancreatitis]])

Diarrhea (see Diarrhea, [[Diarrhea]])

Hepatomegaly (see Hepatomegaly, [[Hepatomegaly]])

Nausea/Vomiting (see Nausea/Vomiting, [[Nausea/Vomiting]])

Hematologic Manifestations

Microangiopathic Hemolytic Anemia (MAHA) (see Hemolytic Anemia, [[Hemolytic Anemia]])

Splenomegaly (see Splenomegaly, [[Splenomegaly]])

Thrombocytopenia (see Thrombocytopenia, [[Thrombocytopenia]])


Neurologic Manifestations

General Comments

Major Neurologic Findings

Minor Neurologic Findings

Posterior Reversible Encephalopathy Syndrome (PRES) (see Posterior Reversible Encephalopathy Syndrome, [[Posterior Reversible Encephalopathy Syndrome]]) [MEDLINE]

Renal Manifestations

Acute Kidney Injury (AKI) (see Acute Kidney Injury, [[Acute Kidney Injury]])

Other Manifestations


Plasma Exchange (see Plasmapheresis, [[Plasmapheresis]])

Glucocorticoids (see Corticosteroids, [[Corticosteroids]])

Rituximab (Rituxan) (see Rituximab, [[Rituximab]])

Investigational Therapies