Etiology
Inborn Error of Metabolism
- Gaucher disease
- Niemann-Pick Disease
Infection
- Infectious Hepatitis
- Cytomegalovirus
- Malaria
- Babesiosis
Lymphoproliferative/Myeloproliferative Disease
- Lymphoma (see Lymphoma, [[Lymphoma]])
- Chronic Lymphocytic Leukemia (see Chronic Lymphocytic Leukemia, [[Chronic Lymphocytic Leukemia]])
- Chronic Myeloid Leukemia (see Chronic Myeloid Leukemia, [[Chronic Myeloid Leukemia]])
- Polycythemia Vera (see Polycythemia Vera, [[Polycythemia Vera]])
- Essential Thrombocytosis (see Essential Thrombocytosis, [[Essential Thrombocytosis]])
Hematologic Defects
- Hereditary Spherocytosis (see Hereditary Spherocytosis, [[Hereditary Spherocytosis]])
- Paroxysmal Nocturnal Hemoglobinuria (PNH) (see Paroxysmal Nocturnal Hemoglobinuria, [[Paroxysmal Nocturnal Hemoglobinuria]])
- Thalassemia
Vascular congestion
- Congestive Heart Failure (see Congestive Heart Failure, [[Congestive Heart Failure]])
- Cirrhosis (see Cirrhosis, [[Cirrhosis]])
Immunologic Disease
- Systemic Lupus Erythematosus (see Systemic Lupus Erythematosus, [[Systemic Lupus Erythematosus]])
- Felty Syndrome (see Felty Syndrome, [[Felty Syndrome]])
- Autoimmune Lymphoproliferative Disorder
Clinical
Asymptomatic Splenomegaly
Hypersplenism
- Physiology: splenic sequestration of one or more cell lines with destruction
- Diagnosis: Extravascular Hemolysis
- elevated retic count
- Smear: immature WBC and platelets
- BM Biopsy: normo-hypercellular marrow without evidence of impaired production
- Clinical
- Thrombocytopenia (see Thrombocytopenia, [[Thrombocytopenia]])
- Treatment: Treat underlying disease, Splenectomy
References
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