Plasminogen Activator Inhibitor-1 (PAI-1) Deficiency

Epidemiology

  • xxx

Physiology

  • Heterozygous: no abnormal bleeding (even after surgery)
  • Homozygous: delayed bleeding after surgery or trauma
    • Suggests that initial hemostatic response is normal, but that clots were lysed prematurely due to excessive fibrinolysis

Diagnosis

  • xxx

Clinical Manifestations

Hematologic Manifestations

  • Coagulopathy with Hemorrhage (see Coagulopathy, [[Coagulopathy]])
    • Menorrhagia (see xxxx, [[xxxx]])
    • Prolonged Wound Healing

Treatment


References

  • xxx