Langerhans Cell Histiocytosis (LCH)

Definition of Histiocyte (see Histiocytic Disorders, [[Histiocytic Disorders]])



Risk Factors



Skeletal Survey

Tissue Biopsy

Clinical Subtypes of Langerhans Cell Histiocytosis

Single Organ System Langerhans Cell Histiocytosis

Multi-Organ System Langerhans Cell Histiocytosis

Clinical Manifestations

General Features

Dermatologic Manifestations

Endocrinologic Manifestations

Diabetes Insipidus (see Diabetes Insipidus, [[Diabetes Insipidus]])

Panhypopituitarism (see Panhypopituitarism, [[Panhypopituitarism]])

Other Endocrine Abnormalities

Gastrointestinal Manifestations

Hematologic Manifestations

Neurologic Manifestations

General Comments

Mass Lesions in Brain Parenchyma/Choroid Plexus

Neurodegenerative Symptoms

Posterior Pituitary Involvement with Diabetes Insipidus (see Diabetes Insipidus, [[Diabetes Insipidus]])

Orbital Lesions with Proptosis (see Proptosis, [[Proptosis]])

Otolaryngologic Manifestations

Pulmonary Manifestations

General Comments

Chest Wall Mass

Hilar/Mediastinal Lymphadenopathy (see Mediastinal Mass, [[Mediastinal Mass]])

Increased Risk of Specific Neoplasms

Interstitial Lung Disease (see Interstitial Lung Disease, [[Interstitial Lung Disease]])

Pulmonary Hypertension (see Pulmonary Hypertension, [[Pulmonary Hypertension]])

Spontaneous Pneumothorax (see Pneumothorax, [[Pneumothorax]])

Rheumatologic Manifestations

General Comments

Osteolytic Bone Lesions (see Bone Metastases, [[Bone Metastases]])

Other Manifestations


Single Organ System Disease Treatment Options

Single Bone Lesions in Central Nervous System Risk Area (Orbit/Mastoid/Temporal/Sphenoid Bones)

Single Bone Lesions in Non-Central Nervous System Risk Area (Frontal/Occipital/Parietal Bones) or Other Bone

Bone Lesions in Axial/Appendicular Skeleton

Spine/Femoral Bone Lesions

Solitary Lymph Node Involvement

Isolated Skin Involvement

Pulmonary Langerhans Cell Histiocytosis Treatment Options

Multi-Organ System Disease Treatment Options

Induction Chemotherapy

Maintenance Chemotherapy

Multi-Focal Bone Disease Treatment Options

Central Nervous System Disease Treatment Options

Central Nervous System Mass Lesions

Neurodegenerative Disease

Disease Which Resembles Both Erdheim-Chester Disease and Langerhans Cell Histiocytosis