Histiocytic Disorders

Definition of Histiocyte

Histiocyte is an Outdated Term Used to Describe Large White Blood Cells Which are Resident in Tissues: various cells may be classified as histiocytes
- Dermal/Interstitial Dendritic Cells
- Langerhans Cells
- Monocytes/Macrophages

Classification of Histiocytic Disorders

Benign Disorders with Variable Biologic Behavior

Dendritic Cell-Related Disorders

Langerhans Cell Histiocytosis (LCH) (see Langerhans Cell Histiocytosis, [[Langerhans Cell Histiocytosis]])
Erdheim-Chester Disease (ECD)
Juvenile Xanthogranuloma (JXG)
Solitary Histiocytomas with Juvenile Xanthogranuloma Phenotype
Secondary Dendritic Cell Disorders

Macrophage-Related Disorders

Hemophagocytic Lymphohistiocytosis (HLH) (Primary Hemophagocytic Syndrome)
- Familial
- Sporadic
Secondary Hemophagocytic Syndrome
- Infection
  - Adenovirus (see Adenovirus, [[Adenovirus]])
  - Cytomegalovirus (CMV) (see Cytomegalovirus, [[Cytomegalovirus]])
  - Dengue Virus (see Dengue Virus, [[Dengue Virus]])
  - Epstein-Barr Virus (EBV) (see Epstein-Barr Virus, [[Epstein-Barr Virus]])
  - Herpes Simplex Virus (HSV) (see Herpes Simplex Virus, [[Herpes Simplex Virus]]
  - Human Immunodeficiency Virus (HIV) (see Human Immunodeficiency Virus, [[Human Immunodeficiency Virus]])
  - Human Herpesvirus 6 (see Human Herpesvirus 6, [[Human Herpesvirus 6]])
  - Human Herpesvirus 8 (see Human Herpesvirus 8, [[Human Herpesvirus 8]])
  - Influenza A Virus (see Influenza Virus, [[Influenza Virus]]): antigenic type H1N1
  - Measles Virus (see Measles Virus, [[Measles Virus]])
  - Merkel Cell Polyomavirus
  - Mumps Virus (see Mumps Virus, [[Mumps Virus]])
  - Parainfluenza Virus (see Parainfluenza Virus, [[Parainfluenza Virus]]): type III
  - Parvovirus B19 (see Parvovirus B19, [[Parvovirus B19]])
  - Rubella Virus (see Rubella Virus, [[Rubella Virus]])
  - Varicella-Zoster Virus (VZV) (see xxxx, [[Varicella-Zoster Virus]])
  - Viral Hepatitis (see Hepatitis A Virus, [[Hepatitis A Virus]], Hepatitis B Virus, [[Hepatitis B Virus]], and Hepatitis C Virus, [[Hepatitis C Virus]])
- Malignancy
  - Extranodal NK/T-Cell Lymphoma, Nasal Type (ENKL) (see Extranodal NK/T-Cell Lymphoma, Nasal Type, [[Extranodal NK, T-Cell Lymphoma, Nasal Type]])
  - Aggressive NK Cell Leukemia (ANKL) (see NK Cell Leukemia, [[NK Cell Leukemia]])
- Autoimmune/Macrophage Activation Syndrome (MAS)
  - Adult-Onset Still’s Disease (see Adult-Onset Still’s Disease, [[Adult-Onset Stills Disease]])
  - Juvenile Rheumatoid Arthritis (JRA)/Systemic-Onset Juvenile Idiopathic Arthritis (SoJIA)
  - Kawasaki Disease (see Kawasaki Disease, [[Kawasaki Disease]])
  - Systemic Lupus Erythematosus (SLE) (see Systemic Lupus Erythematosus, [[Systemic Lupus Erythematosus]])

Other

Rosai-Dorfman Disease (RD): sinus histiocytosis with massive lymphadenopathy
Solitary Histiocytoma of Macrophage Phenotype

Malignant Disorders

Monocyte-Associated
- Leukemias
  - Acute Monocytic Leukemia (M5A, M5B)
  - Acute Myelomonocytic Leukemia (M4)
  - Chronic Myelomonocytic Leukemia
- Extramedullary Monocytic Tumor or Sarcoma
Dendritic Cell-Related Histiocytic Sarcoma: localized or disseminated
Macrophage-Related Histiocytic Sarcoma: localized or disseminated

References

xxxx