HELLP Syndrome


Physiology


Diagnosis

Smear: polychromatophilia/ RBC fragments (schistocytes), helmet cells/nucleated RBC

CBC: thrombocytopenia

LFT’s: elevated

BM Bx: erythroid hyperplasia


Clinical

2) Heme:
a) Microangiopathic Hemolytic Anemia (MAHA): schistocytes on smear due to intravascular hemolysis
b) Thrombocytopenia: plt count <100k/mm3

3) Neuro:
a)

4) Other:
a) Malaise:
b) Non-Dependent Edema:
c) HTN: may be absent early in course
d)


Treatment

Immediate Delivery: best choice in cases with a viable fetus

Surigcal Management: indicated for shock, severe RUQ pain, and acute abdomen (as these indicate probable rupture of a subcapsular hepatic hematoma)


Prognosis


References