Hairy Cell Leukemia
Pathogenesis
Clinical
- Asymptomatic (25% of cases)
- Splenomegaly
- Pancytopenia
- Low Monocyte Count: increased risk of infections
- “Fried-Egg” Appearance of Cells
Treatment
- Indications for Treatment
- Splenomegaly
- Significant Cytopenias
- Agents
- Cladribine (aka 2-Chlordeoxyadenosine) (see Cladribine, [[Cladribine]]): purine analogue
- Pentostatin (see Pentostatin, [[Pentostatin]])
- Rituximab (see Anti-CD20 Therapy, [[Anti-CD20 Therapy]])
- Anti-CD22 Therapy (see Anti-CD22 Therapy, [[Anti-CD22 Therapy]])
- CAT-3888 (aka BL22): anti-CD22 complexed with Pseudomonas exotoxin PE38
- CAT-8015 (aka HA22, Moxetumomab Pasudotox): anti-CD22 complexed with PE38 (a 38-kDa portion of Pseudomonas exotoxin A)
- Vemurafenib (Zelboraf) (see Vemurafenib, [[Vemurafenib]]): 1 case report from NEJM
References