Epidemiology

• Following bone marrow transplant (see Bone Marrow Transplant)

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Physiology

• xxx

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Diagnosis

• xxx

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Clinical Manifestations

Acute Graft vs Host Disease (Acute GVHD)

Cardiovascular Manifestations

• Sepsis-Like Syndrome with Hypotension (see Hypotension, [[Hypotension]]): can occur in acute GVHD

Dermatologic Manifestations

• Maculopapular Rash (see Exanthems, [[Exanthems]]): typically first appears on dorsal hands and forearms during acute GVHD

Infectious Manifestations

• Increased Risk of Cytomegalovirus (CMV) Infection (see Cytomegalovirus, [[Cytomegalovirus]])

Hepatic Manifestations

• Cholestatic Hyperbilirubinemia (see Hyperbilirubinemia, [[Hyperbilirubinemia]])

Lower Gastrointestinal Tract Manifestations

• Abdominal Pain (see Abdominal Pain, [[Abdominal Pain]])
• Ileus (see Ileus, [[Ileus]])
• Watery or Bloody Diarrhea (see Diarrhea, [[Diarrhea]])

Upper Gastrointestinal Tract Manifestations

• Anorexia
• Nausea (see Nausea and Vomiting, [[Nausea and Vomiting]])

Chronic Graft vs Host Disease (Chronic GVHD)

Cardiovascular Manifestations

• Constrictive Pericarditis (see Constrictive Pericarditis, [[Constrictive Pericarditis]])

Dermatologic Manifestations

• Dyspigmentation
• Alopecia (see Alopecia, [[Alopecia]])
• Poikiloderma
• Lichen Planus-Like Lesions
• Sclerotic Lesions

Female Genital Manifestations

• Vaginal Sclerosis
• Vaginal Ulcerations

Gastrointestinal Tract Manifestations

• Anorexia (see Anorexia, [[Anorexia]])
• Weight Loss (see Weight Loss, [[Weight Loss]])
• Esophageal Web/Stricture (see xxxx, [[xxxx]])

Hematologic Manifestations

• Anemia (see Anemia, [[Anemia]])
• Neutropenia (see Neutropenia, [[Neutropenia]])
• Thrombocytopenia (see Thrombocytopenia, [[Thrombocytopenia]])

Hepatic Manifestations

• Hyperbilirubinemia (see Hyperbilirubinemia, [[Hyperbilirubinemia]])
• Transaminitis (see xxxx, [[xxxx]])

Musculoskeletal Manifestations

• Fasciitis
• Myositis (see Myositis, [[Myositis]])
• Joint Stiffness/Contractures

Nail Manifestations

• Nail Dystrophy
• Nail Loss

Ocular Manifestations

• Dry Eyes/Sicca Syndrome
• Cicatricial Conjunctivitis

Oral Manifestations

• Lichen-Type Lesions
• Oral Ulcers (see Oral Ulcers, [[Oral Ulcers]])
• Restricted Oral Opening Due to Sclerosis
• Xerostomia

Pulmonary Manifestations

• Restrictive/Obstructive Pulmonary Function Test (PFT) Abnormalities (see Obstructive Lung Disease, [[Obstructive Lung Disease]])
• Bronchiolitis Obliterans (BO) (see Bronchiolitis Obliterans, [[Bronchiolitis Obliterans]])
• Transudative Pleural Effusion (see Pleural Effusion-Transudate, [[Pleural Effusion-Transudate]])

Renal Manifestations

• Nephrotic Syndrome (see Nephrotic Syndrome, [[Nephrotic Syndrome]]): rare

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Treatment

Acute Graft vs Host Disease (Acute GVHD)

• xxx

Chronic Graft vs Host Disease (Chronic GVHD)

• xxx

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References

• Unexplained effusions: association with allogeneic bone marrow transplantation and acute or chronic graft-versus-host disease. Bone Marrow Transplant. 1996 Feb;17(2):207-11 [MEDLINE]
• Constrictive Pericarditis Due to Graft-vs-Host Disease. Mayo Clin Proc. Dec 2010; 85(12): e90 [MEDLINE]