Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency



  • Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency Occurs with Increased Incidence in African-Americans, Mediterranean Descent, Southeast Asians


Blood Glucose-6-Phosphate Dehydrogenase (G6PD) (see Glucose-6 Phosphate Dehydrogenase, Glucose-6 Phosphate Dehydrogenase)

  • Technique
    • Whole Blood Sample: collected in lavender EDTA top tube, green top heparinized tube, and yellow top ACD tube
    • Sample Must Not Be Hemolyzed
  • Interpretation
    • Decreased

Nitroblue Tetrazolium Test (NBT) (see Nitroblue Tetrazolium Test, Nitroblue Tetrazolium Test)

Clinical Manifestations

Hematologic Manifestations

Hemolytic Anemia (see Hemolytic Anemia, Hemolytic Anemia)

Other Manifestations

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  • Methemoglobinemia and hemolytic anemia after rasburicase administration in a child with leukemia. Int J Clin Pharm. 2011 Feb;33(1):58-60. doi: 10.1007/s11096-011-9484-3. Epub 2011 Feb 4 [MEDLINE]
  • Rasburicase causing severe oxidative hemolysis and methemoglobinemia in a patient with previously unrecognized glucose-6-phosphate dehydrogenase deficiency. Acta Haematol. 2013;130(4):254-9. doi: 10.1159/000351048. Epub 2013 Jul 11 [MEDLINE]