Cullen’s Sign


  • First Description: by Dr. Thomas Stephen Cullen in 1918 in association with ruptured ectopic pregnancy
    • In 1919, Turner described a “dirty green” discoloration of the loin in association with acute pancreatitis (see Grey Turner’s Sign, [[Grey Turners Sign]])


  • Abdominal Trauma
  • Acute Pancreatitis (see Acute Pancreatitis, [[Acute Pancreatitis]]): due to methemalbumin formed from digested blood tracking around the abdominal wall from the inflamed pancreas
  • Retroperitoneal Hemorrhage (see Retroperitoneal Hemorrhage, [[Retroperitoneal Hemorrhage]])
  • Ruptured Ectopic Pregnancy (see Ectopic Pregnancy, [[Ectopic Pregnancy]])


  • Peri-Umbilical Ecchymosis


  • Coexistence of Cullen’s and Grey Turner’s signs in acute pancreatitis. Am J Med. 2009 Apr;122(4):333-4. doi: 10.1016/j.amjmed.2008.08.032 [MEDLINE]