(acute generalized eruption)
Etiology
Morbilliform (Measles-Like): erythematous maculopapular rash
- Acute Graft vs Host Disease (GVHD) (see Graft vs Host Disease): lesions typically begin on the dorsal hands and forearms
- Contact Dermatitis (see Contact Dermatitis)
- Drugs: drug-induced morbilliform rash is typically associated with eosinophilia, fever, transient lymphadenopathy, and pruritus -> DRESS Syndrome (see Drug Rash with Eosinophilia and Systemic Symptoms)
- Allopurinol (see Allopurinol)
- Carbamazepine (see Carbamazepine)
- Dapsone (see Dapsone)
- Lamotrigine (Lamictal) (see Lamotrigine)
- Minocycline (see Minocycline)
- Modafinil (see Modafinil)
- Nevirapine (see Nevirapine)
- Penicillins (see Penicillins)
- Phenobarbital (see Phenobarbital)
- Phenytoin (Dilantin) (see Phenytoin)
- Sulfasalazine (Azulfidine) (see Sulfasalazine)
- Sulfonamides (see Sulfonamides)
- Infection
- Bacterial
- Meningococcemia (see Meningococcemia): morbilliform rash may occur prior to the development of purpura
- Rickettsial Infection (see Rocky Mountain Spotted Fever): morbilliform rash may occur early in course
- Syphilis (see Syphilis): morbilliform rash may occur during early secondary syphilis
- Typhoid Fever (see Typhoid Fever): macular rose spots predominantly involve the anterior trunk
- Viral
- Adenovirus (see Adenovirus)
- Coxsackie Virus (see Coxsackie Virus)
- Cytomegalovirus (CMV) (see Cytomegalovirus)
- Dengue Virus (see Dengue Virus)
- Echovirus (see Echovirus)
- Epstein-Barr Virus (EBV)/Infectious Mononucleosis (see Epstein-Barr Virus)
- Measles (Rubeola) (see Measles)
- Prodrome: coryza, cough, conjunctivitis, Koplik’s spots on buccal mucosa
- Rash begins behind ears, at hairline, and on forehead -> spreads down body, typically with confluence
- Parvovirus B19/Erythema Infectiosum (Fifth Disease) (see Erythema Infectiosum)
- Facial erythema (“slapped sace”) -> progresses to reticulated morbilliform rash on extremities
- Rubella (German Measles) (see Rubella): rash begins on forehead and face -> spreads down body (rash resolves in the same order)
- Associated with retroauricular and suboccipital lymphadenopathy
- Varicella-Zoster Virus (VZV)/Chickenpox (see Varicella-Zoster Virus): morbilliform rash may occur early, prior to development of vesicles
- West Nile Virus (see West Nile Virus)
- Bacterial
- Kawasaki Disease (see Kawasaki Disease)
Scarlatiniform (Scarlet Fever-Like): blanching erythematous rash
- See Erythroderma
References
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