If Torsades: Magnesium Sulfate (MgSO4) (see Magnesium Sulfate, [[Magnesium Sulfate]]): 1-2 IV over 1-2 min
If Unknown or AF with WPW: Amiodarone (see Amiodarone, [[Amiodarone]]) 150 mg over 10 min (max: 2.2 g/24 hrs) -> Drip 1 mg/min x 6 hrs, then 0.5 mg/min x 18 hrs
Avoid AV nodal blocking agents with irregular wide-complex tachycardia of unknown etiology (ie: possible WPW), as these can cause paradoxical increase in HR or degeneration to VF in WPW
Unstable
Defbrillate: 200 J
If Torsades: Magnesium Sulfate (MgSO4) (see Magnesium Sulfate, [[Magnesium Sulfate]]): 1-2 IV over 1-2 min
Low End-Tidal pCO2 In Intubated Patients After 20 min of CPR: strongly associated with failure of resuscitation
Not to be used in non-intubated patients
Not to be used in isolation to determine if resuscitation should be discontinued
Extra-Corporeal Membrane Oxygenation (ECMO)/Percutaneous Cardiopulmonary Support (CPS) (see Percutaneous Cardiopulmonary Support, [[Percutaneous Cardiopulmonary Support]])
May Be Considered for Select Patients with Refractory Cardiac Arrest
Use of Vasopressors During Cardiac Arrest
To date no placebo-controlled trials have shown that administration of any vasopressor agent at any stage during management of VF, pulseless VT, PEA, or asystole increases the rate of neurologically intact survival to hospital discharge
There is evidence, however, that the use of vasopressor agents is associated with an increased rate of return of spontaneous circulation
Endotracheal Drug Administration (Via ETT) During Cardiac Arrest
Generally Considered to be Inferior to Intravenous Drug Administration
Typical ETT Drug Dose is 2.5x the Intravenous Dose
Lidocaine, Epinephrine, Atropine, Naloxone, and Vasopressin are Absorbed via ETT Administration
There is no data regarding using amiodarone via ETT
Endotracheal Intubation During Cardiac Arrest
Timing of Intubation During CPR
Some Studies Demonstrate Improved Survival with Intubation in <12 min
Some Studies Demonstrate No Increase in Return of Spontaneous Circulation, but Improved 24 hr Survival with Intubation in <5 min
Advantages of Intubation During CPR
Elimination of the Need for Pauses in Chest Compressions for Ventilation
Potentially Improved Ventilation and Oxygenation
Reduction in the Risk of Aspiration
Ability to Use Quantitative Waveform Capnography During CPR
To Monitor Quality of CPR
To Optimize Chest Compressions
To Allow Detection of Return of Spontaneous Circulation During Chest Compressions or When a Rhythm Check Reveals an Organized Rhythm
Disadvantages of Intubation During CPR
Interruptions in Chest Compression During Intubation
Risk of Unrecognized Esophageal Intubation
Confirmation of Endotracheal Tube (ETT) Placement During CPR
Continuous Waveform Capnography: Class I Recommendation
Tracheal Ultrasound
References
Part 1: Executive Summary: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. 2015 Nov 3;132(18 Suppl 2):S315-67. doi: 10.1161/CIR.0000000000000252 [MEDLINE]
Part 2: Evidence Evaluation and Management of Conflicts of Interest: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. 2015 Nov 3;132(18 Suppl 2):S368-82. doi: 10.1161/CIR.0000000000000253 [MEDLINE]
Part 3: Ethical Issues: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. 2015 Nov 3;132(18 Suppl 2):S383-96. doi: 10.1161/CIR.0000000000000254 [MEDLINE]
Part 4: Systems of Care and Continuous Quality Improvement: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. 2015 Nov 3;132(18 Suppl 2):S397-413. doi: 10.1161/CIR.0000000000000258 [MEDLINE]
Part 5: Adult Basic Life Support and Cardiopulmonary Resuscitation Quality: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. 2015 Nov 3;132(18 Suppl 2):S414-35. doi: 10.1161/CIR.0000000000000259 [MEDLINE]
Part 6: Alternative Techniques and Ancillary Devices for Cardiopulmonary Resuscitation: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. 2015 Nov 3;132(18 Suppl 2):S436-43. doi: 10.1161/CIR.0000000000000260 [MEDLINE]
Part 7: Adult Advanced Cardiovascular Life Support: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. 2015 Nov 3;132(18 Suppl 2):S444-64. doi: 10.1161/CIR.0000000000000261 [MEDLINE]
Part 8: Post-Cardiac Arrest Care: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. 2015 Nov 3;132(18 Suppl 2):S465-82. doi: 10.1161/CIR.0000000000000262 [MEDLINE]
Part 9: Acute Coronary Syndromes: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. 2015 Nov 3;132(18 Suppl 2):S483-500. doi: 10.1161/CIR.0000000000000263 [MEDLINE]
Part 10: Special Circumstances of Resuscitation: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. 2015 Nov 3;132(18 Suppl 2):S501-18. doi: 10.1161/CIR.0000000000000264 [MEDLINE]
Part 11: Pediatric Basic Life Support and Cardiopulmonary Resuscitation Quality: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. 2015 Nov 3;132(18 Suppl 2):S519-25. doi: 10.1161/CIR.0000000000000265 [MEDLINE]
Part 12: Pediatric Advanced Life Support: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. 2015 Nov 3;132(18 Suppl 2):S526-42. doi: 10.1161/CIR.0000000000000266 [MEDLINE]
Part 13: Neonatal Resuscitation: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. 2015 Nov 3;132(18 Suppl 2):S543-60. doi: 10.1161/CIR.0000000000000267 [MEDLINE]
Part 14: Education: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. 2015 Nov 3;132(18 Suppl 2):S561-73. doi: 10.1161/CIR.0000000000000268 [MEDLINE]