Subdivisions of the Immune System
Innate Immune System
- Function: immune system present from birth
- This is a more “primitive” component of the immune system: provides “first-line” defense
- The cardinal signs of inflammaton (tumor = swelling, rubor = redness, calor = heat, dolor = pain) are manifestations of the innate immune system response
- Recognition of organisms via pattern-recognition receptors (PRR’s): these recognize “non-self” antigens from the invading organisms
- Innate immune system acts immediately to respond to an infection/exposure
- Innate immune system activates and instructs the actions of the adaptive immune system
- Innate immune system regulates inflammation, maintaining immunologic homeostasis
- Components
- Non-Cellular Components of the Innate Immune System
- Physical Barriers to Invasion: tight junctions in the skin, epithelial and mucous membrane surfaces, mucus itself)
- Cell Surface Receptors that Detect Microorganisms and Initiate a Defensive Response: Toll‐like receptors, etc
- Epithelial and phagocytic cell enzymes (eg, lysozyme) which selectively disrupt microbial cell membranes
- Inflammation‐related serum proteins (eg, complement which also disrupts microbial membranes, C‐reactive protein, lectins such as mannose‐binding lectin and ficolins, hemopexin and haptoglobin, which deny iron to invasive microbes)
- Surface and phagocyte granule antimicrobial peptides (defensins, cathelicidin, and many more)
- Cellular Components of the Innate Immune System
- Phagocytes: myelocytic neutrophils, monocytes, and macrophages
- Inflamamtory Cells Which Release Cytokines and Other Mediators: macrophages, mast cells, lymphoid natural‐killer (NK) cells
Adaptive Immune System
- Function: immune system that evolves over lifetime of exposure to micro-organisms in the environment
- This is a more “modern” component of the immune system: provides more sophisticated, but delayed defense
- Antigen‐specific responses to a foreign antigen or pathogen: typically requires days-weeks to fully respond
- Cells exposed to microbial antigens are selected for clonal expansion
- Immunologic Priming: initial contact with an antigen -> subsequent antigen exposure leads to more rapid and vigorous immune responses (ie: immunologic memory)
- Components: both are derived from a common progenitor cell
- T-Lymphocytes: principal effectors of antigen-mediated cellular immunity
- Cell-mediated immunity is responsible for defense against pathogens that replicate intracellularly (viruses, mycobacteria, and some bacteria), cells which exhibit aberrant differentiation (neoplasms), and allogenic cells (graft rejection)
- T-cell responses are initiated by antigen-presenting cells: dendritic cells and monocytes/macrophages (note: monocytes may also differentiate into dendritic cells)
- T-cell clonal expansion subsequently occurs
- T cells are categorized on the basis of the pattern of cytokines that they secrete, which results in either humoral immune response (TH2) or cell‐mediated immune response (TH1)
- B-Lymphocytes: principal effectors of humoral immunity
- B-cells are activated after T-cells -> antibodies are produced when B cells encounter antigens and subsequently undergo activation, proliferation, and differentiation
- Neonates rely predominantly on maternal IgG (passed through the placenta) and maternal IgA (transferred through colostrum and breast milk)
- After infancy, the child’s immunoglobulins gradually increase as levels of maternal antibodies wane
- Location
- T cell precursors arise from hematopoietic stem cells and home to the thymus for maturation
- Mature T-cells, B-cells, monocytes, and dendritic cells enter the circulation -> home to peripheral lymphoid organs (lymph nodes, spleen), mucosal surface‐associated lymphoid (MALT) tissue (gut, genitourinary, and respiratory tracts), skin, and mucous membranes
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