Naloxone (Narcan)
Indications
- Ileus (see Ileus, [[Ileus]])
- Opiate Intoxication (see Opiates, [[Opiates]])
Pharmacology
- Opiate Receptor Antagonist
- Reversal of respiratory depression by partial agonists or mixed agonists/antagonists (pentazocine, buprenorphine) may be incomplete
Administration
- PO (treatment of ileus):
- IV (treatment of opiate intoxication): 1 amp (0.4 mg) PRN
- Evzio SQ/IV Auto-Injector (treatment of opiate Intoxication): 0.4 mg single-use injector that may be administered by family member or caregiver
Adverse Effects
Cardiovascular Adverse Effects
- Cardiac Arrest (see Cardiac Arrest, [[Cardiac Arrest]]): may occur with post-op naloxone administration
- Hypertension (see Hypertension, [[Hypertension]]): may occur with post-op naloxone administration
- Hypotension (see Hypotension, [[Hypotension]]): may occur with post-op naloxone administration
- Ventricular Fibrillation (see Ventricular Fibrillation, [[Ventricular Fibrillation]]): may occur with post-op naloxone administration
- Ventricular Tachycardia (see Ventricular Tachycardia, [[Ventricular Tachycardia]]): may occur with post-op naloxone administration
Neurologic Adverse Effects
- Agitation: may occur with post-op naloxone administration
Pulmonary Adverse Effects
Other Adverse Effects
- Opiate Withdrawal (see Opiates, [[Opiates]]): in patients with opiate dependence
References