Indications

• Peripheral Edema (see Peripheral Edema, [[Peripheral Edema]])

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Pharmacology

• Epithelial Sodium Channel (ENaC) Antagonist (see Epithelial Sodium Channel Antagonists, [[Epithelial Sodium Channel Antagonists]]): these agents act to close sodium channels on the luminal membrane of cells in the collecting tubule (collecting tubule is the site of action of aldosterone)
  • Inhibits sodium reabsorption in the late distal convoluted tubules, connecting tubules, and collecting ducts
  • Acts as potassium-sparing diuretic
  • Same mechanism as that of Amiloride (see Amiloride, [[Amiloride]])

Metabolism

• xxxx

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Administration

• PO (Dyazide): xxx
• PO (Maxzide): xxx

Dose Adjustment

• xxxx

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Adverse Effects

Renal Adverse Effects

Acute Interstitial Nephritis (see Acute Interstitial Nephritis, [[Acute Interstitial Nephritis]])

• xxx

Hypoaldosteronism (see Hypoaldosteronism, [[Hypoaldosteronism]])

• Physiology: due to epithelial sodium channel (ENaC) antagonism in renal collecting tubule
• Clinical
  • Hyperkalemia (see Hyperkalemia, [[Hyperkalemia]])

Other Adverse Effects

• xxxx
• xxxx
• xxxx
• xxxx

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References

• xxx