Triamterene (Dyrenium, Dyazide, Maxzide)

Indications

Pharmacology

  • Epithelial Sodium Channel (ENaC) Antagonist (see Epithelial Sodium Channel Antagonists, [[Epithelial Sodium Channel Antagonists]]): these agents act to close sodium channels on the luminal membrane of cells in the collecting tubule (collecting tubule is the site of action of aldosterone)
    • Inhibits sodium reabsorption in the late distal convoluted tubules, connecting tubules, and collecting ducts
    • Acts as potassium-sparing diuretic
    • Same mechanism as that of Amiloride (see Amiloride, [[Amiloride]])

Metabolism

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Administration

  • PO (Dyazide): xxx
  • PO (Maxzide): xxx

Dose Adjustment

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Adverse Effects

Renal Adverse Effects

Acute Interstitial Nephritis (see Acute Interstitial Nephritis, [[Acute Interstitial Nephritis]])

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Hypoaldosteronism (see Hypoaldosteronism, [[Hypoaldosteronism]])

  • Physiology: due to epithelial sodium channel (ENaC) antagonism in renal collecting tubule
  • Clinical

Other Adverse Effects

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References

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