Indications
- Peripheral Edema (see Peripheral Edema, [[Peripheral Edema]])
Pharmacology
- Epithelial Sodium Channel (ENaC) Antagonist (see Epithelial Sodium Channel Antagonists, [[Epithelial Sodium Channel Antagonists]]): these agents act to close sodium channels on the luminal membrane of cells in the collecting tubule (collecting tubule is the site of action of aldosterone)
- Inhibits sodium reabsorption in the late distal convoluted tubules, connecting tubules, and collecting ducts
- Acts as potassium-sparing diuretic
- Same mechanism as that of Amiloride (see Amiloride, [[Amiloride]])
Metabolism
- xxxx
Administration
- PO (Dyazide): xxx
- PO (Maxzide): xxx
Dose Adjustment
- xxxx
Adverse Effects
Renal Adverse Effects
Acute Interstitial Nephritis (see Acute Interstitial Nephritis, [[Acute Interstitial Nephritis]])
- xxx
Hypoaldosteronism (see Hypoaldosteronism, [[Hypoaldosteronism]])
- Physiology: due to epithelial sodium channel (ENaC) antagonism in renal collecting tubule
- Clinical
- Hyperkalemia (see Hyperkalemia, [[Hyperkalemia]])
Other Adverse Effects
- xxxx
- xxxx
- xxxx
- xxxx
References
- xxx