Mannitol (Osmitrol, Resectisol)


Treatment of Increased Intracranial Pressure (ICP) (see Increased Intracranial Pressure, Increased Intracranial Pressure): intravenous mannitol administration

Trans-Urethral Resection of the Prostate (TURP) (see Benign Prostatic Hypertrophy, Benign Prostatic Hypertrophy)



Genitourinary Irrigation


Mannitol is an Osmotic Diuretic




IV (Treatment of Increased Intracranial Pressure) (see Increased Intracranial Pressure, Increased Intracranial Pressure)

Dose Adjustment

Use in Pregnancy (see Pregnancy, Pregnancy)

Use in Lactation

Drug Interactions

Adverse Effects

Renal Adverse Effects

Other Adverse Effects

Adverse Reactions (Frequency not defined):
Cardiovascular: Chest pain, cardiac failure, hypertension, hypotension, local thrombophlebitis, peripheral edema, tachycardia
Central nervous system: Chills, dizziness, headache, seizure
Dermatologic: Bullous rash, urticaria
Endocrine & metabolic: Dehydration (secondary to rapid diuresis), dilutional hyponatremia, electrolyte disturbance (increased osmolar gap), fluid and electrolyte disturbance, hypovolemia (secondary to rapid diuresis), hyperglycemia, hyperkalemia (hyperosmolality-induced), hypernatremia, hypervolemia, metabolic acidosis (dilutional), water intoxication
Gastrointestinal: Nausea, vomiting, xerostomia
Genitourinary: Dysuria
Hypersensitivity: Hypersensitivity reaction
Local: Local pain
Ophthalmic: Blurred vision
Renal: Acute renal failure, tubular necrosis (adult dose: >200 g/day; serum osmolality >320 mOsm/L), polyuria
Respiratory: Pulmonary edema, rhinitis
Miscellaneous: Fever, tissue necrosis