Lepirudin (Refludan)
General Information
- Bayer ceased production in 2012
Indications
Pharmacology
- Thrombin Inhibitor (see Factor IIa Inhibitors, [[Factor IIa Inhibitors]])
- Half-Life: 40 min
- Metabolism: renal -> use with caution in renal insufficiency
- Development of Anti-Hirudin Antibodies: occurs in 44% of cases
- Monitor PTT
Administration
Adverse Effects
Hematologic Adverse Effects
Other Adverse Effects
References