Indications
- Hypertension (see Hypertension, [[Hypertension]])
- Migraine Prophylaxis (see Migraines, [[Migraines]])
- Rate Control of AV Nodal-Mediated Arrhythmias
- Atrial Fibrillation with Rapid Ventricular Response (see Atrial Fibrillation, [[Atrial Fibrillation]])
- Supraventricular Tachycardia (SVT) with Rapid Ventricular Response (see Supraventricular Tachycardia, [[Supraventricular Tachycardia]])
Contraindications
Atrioventricular Heart Blocks
- First Degree Atrioventricular Block (First Degree Heart Block) (see First Degree Atrioventricular Block, [[First Degree Atrioventricular Block]]): with P-R interval ≥0.24 sec
- Second Degree Atrioventricular Block-Mobitz Type I (Wenckebach) (see Second Degree Atrioventricular Block-Mobitz Type I, [[Second Degree Atrioventricular Block-Mobitz Type I]])
- Second Degree Atrioventricular Block-Mobitz Type II (see Second Degree Atrioventricular Block-Mobitz Type II, [[Second Degree Atrioventricular Block-Mobitz Type II]])
- Third Degree Atrioventricular Block (Third Degree Heart Block, Complete Heart Block) (see Third Degree Atrioventricular Block, [[Third Degree Atrioventricular Block]])
Hypotension (see xxxx, [[xxxx]])
- Diltiazem Can Exacerbate Hypotension
Pharmacology
- Non-Dihydropyridines (Benzothiazepine) Calcium Channel Blocker (see Calcium Channel Blockers, [[Calcium Channel Blockers]])
- AV Nodal Blockade
- xxx
Administration
- PO:
- IV: 5 mg bolus, then 5-15 mg/hr drip
Adverse Effects
Cardiovascular Adverse Effects
Atrioventricular Heart Blocks
- First Degree Atrioventricular Block (First Degree Heart Block) (see First Degree Atrioventricular Block, [[First Degree Atrioventricular Block]])
- Second Degree Atrioventricular Block-Mobitz Type I (Wenckebach) (see Second Degree Atrioventricular Block-Mobitz Type I, [[Second Degree Atrioventricular Block-Mobitz Type I]])
- Second Degree Atrioventricular Block-Mobitz Type II (see Second Degree Atrioventricular Block-Mobitz Type II, [[Second Degree Atrioventricular Block-Mobitz Type II]])
- Third Degree Atrioventricular Block (Third Degree Heart Block, Complete Heart Block) (see Third Degree Atrioventricular Block, [[Third Degree Atrioventricular Block]])
Bradycardia (see Bradycardia, [[Bradycardia]])
- May Occur
Hypotension (see Hypotension, [[Hypotension]])
- Physiology: class effect (common to all calcium channel blockers)
Other Adverse Effects
- xxx
- xxx
- xxx
- xxx
Calcium Channel Blocker Intoxication
- See Calcium Channel Blockers, [[Calcium Channel Blockers]]
References
- xxx