Indications

• Herpes Simplex Virus (HSV) (see Herpes Simplex Virus, [[Herpes Simplex Virus]])

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Pharmacology

• Anti-Viral

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Administration

• PO: xxx
• IV: xxx

Dose Adjustment

• Hepatic
• Renal

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Adverse Effects

Cardiovascular Adverse Effects

• Hypotension (see Hypotension, [[Hypotension]])

Dermatologic Adverse Effects

• Erythema Multiforme (see Erythema Multiforme, [[Erythema Multiforme]])
• Pruritus (see Pruritus, [[Pruritus]])
• Rash
• Stevens-Johnson Syndrome-Toxic Epidermal Necrolysis (see Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis, [[Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis]])
• Urticaria (see Urticaria-Angioedema, [[Urticaria-Angioedema]])

Gastroenterologic Adverse Effects

• Elevated Liver Function Tests/Hepatitis (see xxxx, [[xxxx]])

Neurologic Adverse Effects (Neurotoxicity)

• Time of Onset: usually develops early during course of treatment
• Mechanism: probably related to high serum concentrations of acyclovir
• Risk Factors for Neurotoxicity
  • Advanced Age
  • Bone Marrow Transplantation
  • Renal Failure
• Neurologic Adverse Effects
  • Ataxia (see Ataxia, [[Ataxia]])
  • Coma (see Obtundation-Coma, [[Obtundation-Coma]])
  • Delirium (see Delirium, [[Delirium]])
  • Dizziness (see Dizziness, [[Dizziness]])
  • Focal Neurologic Signs (see Acute Motor Deficit, [[Acute Motor Deficit]])
  • Guillain-Barre Syndrome (see Guillain-Barre Syndrome, [[Guillain-Barre Syndrome]]): case report in at least one patient receiving acyclovir prophylaxis after allogeneic bone marrow transplant
  • Myoclonus (see Myoclonus, [[Myoclonus]])
  • Parasthesias (see Parasthesias, [[Parasthesias]])
  • Psychosis (see Psychosis, [[Psychosis]])
  • Seizures (see Seizures, [[Seizures]])

Renal Adverse Effects

• Acute Kidney Injury (AKI) (see Acute Kidney Injury, [[Acute Kidney Injury]]): due to intratubular deposition and obstruction

Other Adverse Effects

• Anaphylaxis (see Anaphylaxis, [[Anaphylaxis]])

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References

• xxx