Etiology

• Coxsackie A Virus (see Coxsackie Virus)
• Enterovirus 71 (EV-71) (see Enterovirus 71)

Clinical

• Fever (see Fever, [[Fever]]
• Painful Oral, Facial, and Nasal Skin Lesions or Vesicles (see Vesicular-Bullous Skin Lesions, [[Vesicular-Bullous Skin Lesions]])
• Palmar/Plantar Skin Lesions or Vesicles: rarely pruritic in childhood cases, may be pruritic in adult cases
• Buttock Skin Lesions or Vesicles: may be present in young childhood cases
• Headache
• Irritability: common in children
• Fatigue/Malaise
• Vomiting/Diarrhea
• Anorexia
• Flaccid Paralysis/Meningitis/Encephalitis/Acute Lung Injury/Diffuse Alveolar Hemorrhage: rare

References

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