Epstein-Barr Virus (EBV)


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  • Mono Spot Test: positive

Clinical Presentations

Pulmonary Manifestations

  • Interstitial Lung Disease (see Interstitial Lung Disease-Etiology, [[Interstitial Lung Disease-Etiology]])
  • Lymphocytic Interstitial Pneumonia (see Lymphocytic Interstitial Pneumonia, [[Lymphocytic Interstitial Pneumonia]])
  • Acute Lung Injury-ARDS (see Acute Lung Injury-ARDS, [[Acute Lung Injury-ARDS]])
  • Pleural Effusion (see Pleural Effusion-Exudate, [[Pleural Effusion-Exudate]]): reported with infectious mononucleosis
    • EBV has been detected by real-time PCR in 40% of patients with pleural effusions
    • EBV has been detected by real-time PCR in 59% of patients with unexplained pleural effusions
    • However, EBV has been detected by real-time PCR in 15% of patients with a pleural effusion clearly attributable to another cause

Dermatologic Manifestations

  • Erythema Multiforme (see Erythema Multiforme, [[Erythema Multiforme]])
  • Morbilliform Rash (see Exanthems, [[Exanthems]])
    • In infectious mononucleosis: 95% of patients receiving Ampicillin will develop a rash


  • Eur Respir J. 2000 Apr;15(4):803-6
  • Eur Respir J 2005; 26:566-568]
  • Thijsen SFT, Luderer R, van Gorp JMH, Oudejans SJG, Bossink AWJ. A possible role for Epstein-Barr virus in the pathogenesis of pleural effusion. Eur Respir J 2005;26:662 666