Kaposi Sarcoma




Pleural Bx: usually negative (due to patchy nature of KS lesions)

Pleural fluid: transudate or exudate
-Appearance: serosanguinous or bloody
-CD34-positive cells: detected

Pleural Bx: usually not diagnostic (since KS typically involves visceral pleura >> parietal pleura)

FOB: red or violacious (flat or slightly raised) EB lesions may be seen
-Absence in visible airways does not rule out KS in more distal airways
-EBB/ TBB: usually not diagnostic/ may be hazardous due to risk of bleeding
-TBNA: may be useful for mediastinal nodes

OLB: fails to diagnose KS lesions in some cases

Clinical Presentations

Multisystem disease:
-Lung (lung involvement occurs after mucocutaneous involvement in 90-95% of cases/ lung involvement at autopsy, around 50%, is higher than that detected clinically, around 33% of cases/ 66% of patienst with known pulmonary KS with new CXR findings actually have an opportunistic infection rather than new KS lesions):
1) Progressive dyspnea:
2) Dry cough:
3) Hemoptysis/ chest pain: usually signal precipitous decline
4) Fever: less common (usually signals presence of coexisting infection)
5) Normal exam: may have crackles, etc. though