Irinotecan (Camptosar)

Epidemiology

  • Indications
    • Colon Cancer: either with or without 5-fluorouracil
    • Lung Cancer

Pharmacology

  • Semi-synthetic camptothecin

Adverse Effects

  • Interstitial Pneumonitis (see Interstitial Lung Disease-Etiology)
    • Epidemiology: 1.8% in early Japanese trials
      • In US trials: cough and dyspnea occurred in 20% of cases (although many of these cases had intrathoracic malignancy) -> however, incidence of srioud pulmonary toxicity iwas 0.4%
      • Risk Factors for Toxicity: radition therapy, pre-existing lung disease
    • Diagnosis
      • CXR/Chest CT: reticulonodular infiltrates
    • Clinical: dyspnea, fever
      • Respiratory failure may occur
    • Treatment: corticosteroids may be useful

References

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