Etiology

• Atypical Anti-Psychotics
  • Olanzapine (Zyprexa) (see Olanzapine, [[Olanzapine]])
  • Quetiapine (Seroquel) (see Quetiapine, [[Quetiapine]])
  • Risperidone (Risperdal) (see Risperidone, [[Risperidone]])
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Physiology

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Clinical Manifestations

Cardiovascular Manifestations

• Autonomic Instability
  • Arrhythmias
  • Irregular Blood Pressure
    • Hypertension (see Hypertension, [[Hypertension]])
    • Hypotension (see Hypotension, [[Hypotension]])
  • Irregular Heart Rate
    • Bradycardia (see Bradycardia, [[Bradycardia]])
    • Tachycardia (see Sinus Tachycardia, [[Sinus Tachycardia]])

Neurologic Manifestations

• Altered Mental Status
  • Delirium (see Delirium, [[Delirium]])
  • Obtundation-Coma (see Obtundation-Coma, [[Obtundation-Coma]])

Rheumatologic/Orthopedic Manifestations

• Muscle Rigidity
• Rhabdomyolysis (see Rhabdomyolysis, [[Rhabdomyolysis]])

Other Manifestations

• Diaphoresis: due to autonomic instability
• Fever/Hyperpyrexia (see Fever, [[Fever]])

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Treatment

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References

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