Etiology of Elevated Serum Immunoglobulin E
Atopic Disease
- Allergic Bronchopulmonary Aspergillosis (ABPA) (see Allergic Bronchopulmonary Aspergillosis, [[Allergic Bronchopulmonary Aspergillosis]]): see below
- Allergic Fungal Sinusitis
- Allergic Rhinitis (see Allergic Rhinitis, [[Allergic Rhinitis]])
- Asthma (see Asthma, [[Asthma]]): see below
- Atopic Dermatitis (see Atopic Dermatitis, [[Atopic Dermatitis]])
Immunodeficiency
- Atypical Complete DiGeorge Syndrome
- Hyper IgE-Recurrent Infection Syndrome (Job’s Syndrome, Buckley-Job Syndrome) (see Hyper IgE-Recurrent Infection Syndrome, [[Hyper IgE-Recurrent Infection Syndrome]])
- Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked Syndrome (IPEX)
- Netherton Disease
- Omenn Syndrome
- Wiskott-Aldrich Syndrome
Infectious Disease
- Viral
- Cytomegalovirus (CMV) (see Cytomegalovirus, [[Cytomegalovirus]])
- Epstein-Barr Virus (EBV) (see Epstein-Barr Virus, [[Epstein-Barr Virus]])
- Human Immunodeficiency Virus (HIV) (see Human Immunodeficiency Virus, [[Human Immunodeficiency Virus]])
- Bacterial
- Tuberculosis (see Tuberculosis, [[Tuberculosis]])
- Fungal
- Candida (see Candida, [[Candida]])
- Parasitic
- Ascariasis (see Ascariasis, [[Ascariasis]])
- Schistosomiasis (see Schistosomiasis, [[Schistosomiasis]])
- Strongyloidiasis (see Strongyloidiasis, [[Strongyloidiasis]])
- Tropical Pulmonary Eosinophilia (see Tropical Pulmonary Eosinophilia, [[Tropical Pulmonary Eosinophilia]]): serum IgE usually >10,000 ng/mL (4200 IU/mL)
- Wuchereria Bancrofti
- Brugia Malayi
- Brugia Timori
Inflammatory Disease
- Churg-Strauss Syndrome (Eosinophilic Granulomatosis with Polyangiitis) (see Churg-Strauss Syndrome, [[Churg-Strauss Syndrome]])
- Kimura Disease
Neoplastic Disease
- Hodgkin’s Disease (see Hodgkin’s Disease, [[Hodgkins Disease]])
- IgE Myeloma (see Multiple Myeloma, [[Multiple Myeloma]])
Pulmonary Disease
- Allergic Bronchopulmonary Aspergillosis (ABPA) (see Allergic Bronchopulmonary Aspergillosis, [[Allergic Bronchopulmonary Aspergillosis]])
- Elevated: >1000 IU/mL (International Society for Human and Animal Mycology, ISHAM) (Clin Exp Allergy, 2013) [MEDLINE]
- Generally Higher in ABPA than in Asthma
- May Be as High as 25k IU/mL
- Serum IgE May Decrease (But Does Not Usually Normalize) Following Glucocorticoid Administration
- Elevated: >1000 IU/mL (International Society for Human and Animal Mycology, ISHAM) (Clin Exp Allergy, 2013) [MEDLINE]
- Asthma (see Asthma, [[Asthma]])
- Epidemiology:
- Clinical: xxx
- Cystic Fibrosis (CF) (see Cystic Fibrosis, [[Cystic Fibrosis]])
- Epidemiology: IgE is elevated in 22% of cases
- Clinical: xxx
Other
- Bullous Pemphigoid (see Bullous Pemphigoid, [[Bullous Pemphigoid]])
- Hematopoietic Stem Cell Transplant (HSCT) (see Hematopoietic Stem Cell Transplant, [[Hematopoietic Stem Cell Transplant]])
- Nephrotic Syndrome (see Nephrotic Syndrome, [[Nephrotic Syndrome]])
- Tobacco Abuse (see Tobacco, [[Tobacco]])
References
- Allergic bronchopulmonary aspergillosis: review of literature and proposal of new diagnostic and classification criteria. Clin Exp Allergy. 2013;43(8):850 [MEDLINE]