Pharmacology

• Synthetic derivate of a fermentation product of Aspergillus terreus
• HMG-CoA reductase inhibitor

Adverse Effects

• Acute Lung Injury-ARDS (see Acute Lung Injury-ARDS, [[Acute Lung Injury-ARDS]]): case reports
• Cryptogenic Organizing Pneumonia (see Cryptogenic Organizing Pneumonia, [[Cryptogenic Organizing Pneumonia]])

References

• Statin-induced fibrotic nonspecific interstitial pneumonia. ERJ March 1, 2002 vol. 19 no. 3 577-580
• Eosinophilic pleurisy caused by simvastatin. Rassegna di Patolgia del\’Apparato Respiratorio 2008; 23: 1-3
• Polymyalgia, hypersensitivity pneumonitis and other reactions in patients receiving HMG-CoA reductase inhibitors. Chest 1999; 115: 886-889
• Simvastatin-induced lupus erythematosus. Southern Medical Journal 1998; 91: 873-874
• Interstitial lung disease with pleural effusion caused by simvastin. J Intern Med 1996; 239: 361-363
• Dermatomyositis with lung involvement in a patient treated with simvastatin. Aust NZ J Med 1995; 25: 745-746
• Idiopathic bronchiolitis obliterans with organizing pneumonia. An acute and life-threatening syndrome. Chest 1995; 108: 271-277
• Lupuslike syndrome associated with simvastatin. Arch Intern Med 1992; 152: 1093-1094