Quetiapine (Seroquel)

Indications

Psychosis (see Psychosis, [[Psychosis]])

Pharmacology

Atypical Anti-Psychotic Agent
Serotonin 5-HT3 Receptor Antagonism (ee Serotonin 5-HT3 Receptor Antagonists, [[Serotonin 5-HT3 Receptor Antagonists]])

Physiologic Effects

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Administration

PO:

Adverse Effects

Cardiovascular Adverse Effects

Hypotension/Orthostatic Hypotension (see Hypotension, [[Hypotension]])
Q-T Prolongation without Definite Association with Torsade (see Torsade, [[Torsade]])

Endocrinologic Adverse Effects

Hyperglycemia
Hyperlipidemia
Weight Gain

Rheumatologic/Orthopedic Adverse Effects

Rhabdomyolysis (see Rhabdomyolysis, [[Rhabdomyolysis]])

Renal Adverse Effects

Acute Kidney Injury (AKI) (see Acute Kidney Injury, [[Acute Kidney Injury]])

Other Adverse Effects

Neuroleptic Malignant Syndrome (see Neuroleptic Malignant Syndrome, [[Neuroleptic Malignant Syndrome]])
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References

Atypical Antipsychotic Drugs and the Risk for Acute Kidney Injury and Other Adverse Outcomes in Older Adults: A Population-Based Cohort Study. Ann Intern Med. 2014;161(4):242-248. doi:10.7326/M13-2796