Indications

Hypotension (see Hypotension, [[Hypotension]])

• End-Stage Liver Disease (see End-Stage Liver Disease, [[End-Stage Liver Disease]])
• Sepsis (see Sepsis, [[Sepsis]])
  • Trial of Midodrine During Recovery Phase in Septic Shock (Chest, 2016) [MEDLINE]: midodrine decreases pressor use during the recovery phase of sepsis and may be associated with decreased ICU length of stay

Hepatorenal Syndrome (see Hepatorenal Syndrome, [[Hepatorenal Syndrome]])

• xxxx

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Pharmacology

• Vasoconstriction

Metabolism

• xxx

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Administration

• PO: 10 mg TID

Dose Adjustment

• Hepatic
• Renal

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Adverse Effects

Cardiovascular Adverse Effects

• QT Prolongation without Definite Association with Torsade (see Torsade, [[Torsade]])

Other Adverse Effects

• xxx

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References

• Feasibility, utility, and safety of midodrine during recovery phase from septic shock. Chest. 2016 Mar 4. pii: S0012-3692(16)41575-8. doi: 10.1016/j.chest.2016.02.657 [MEDLINE]