Etomidate Increases the Risk of Adrenal Insufficiency and Mortality Rate in Critically Ill Patients
Meta-Analysis of Etomidate (Crit Care Med, 2012) [MEDLINE]
Etomidate (Used for Rapid Sequence Intubation) is Associated with Increased Risk of Adrenal Insufficiency and Mortality in Patients with Sepsis
Systematic Review/Meta-Analysis of Etomidate in Sepsis (Chest, 2015) [MEDLINE]
Single-Dose Etomidate Does Not Increase Mortality in Sepsis: however, authors noted that the conclusion largely relied on data from observational studies and that randomized trials are further needed
Local Pain at Injection Site: occurs in 30-80% of cases
References
The effect of etomidate on adrenal function in critical illness: a systematic review. Intensive Care Med 2011; 37:901-910. DOI: 10.1007/s00134-011-2160-1 [MEDLINE]
Etomidate is associated with mortality and adrenal insufficiency in sepsis: A meta-analysis. Crit Care Med 2012; 40:2945-2953 [MEDLINE]
Single-dose etomidate does not increase mortality in patients with sepsis: a systematic review and meta-analysis of randomized controlled trials and observational studies. Chest. 2015 Feb;147(2):335-46. doi: 10.1378/chest.14-1012 [MEDLINE]