Indications

• Anaphylaxis (see Anaphylaxis, [[Anaphylaxis]])
• Peptic Ulcer Disease (PUD) (see Peptic Ulcer Disease, [[Peptic Ulcer Disease]])

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Pharmacology

• H2-Histamine Receptor Antagonist (see H2-Histamine Receptor Antagonists, [[H2-Histamine Receptor Antagonists]]
• Epithelial Sodium Channel (ENaC) Antagonist (see Epithelial Sodium Channel Antagonists, [[Epithelial Sodium Channel Antagonists]]): acts to close sodium channels on the luminal membrane of cells in the collecting tubule (collecting tubule is the site of action of aldosterone)

Metabolism

• xxxx

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Administration

• PO:
• IV:

Dose Adjustment

• Hepatic: xxx
• Renal: xxx

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Adverse Effects

Gastrointestinal Adverse Effects

• Acute Pancreatitis (see Acute Pancreatitis, [[Acute Pancreatitis]])
  • Epidemiology: probable association

Other Adverse Effects

• xxxx
• xxxx
• xxxx
• xxxx

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References

• xxx