Indications

• Breast Cancer (see Breast Cancer, [[Breast Cancer]])
• Colorectal Cancer (see Colorectal Cancer, [[Colorectal Cancer]])
• Glioblastoma Multiforme (see Glioblastoma Multiforme, [[Glioblastoma Multiforme]])
• Non-Squamous, Non-Small Cell Lung Cancer (see Lung Cancer, [[Lung Cancer]])
• Ovarian Cancer (see Ovarian Cancer, [[Ovarian Cancer]])
• Renal Cell Carcinoma (see Renal Cancer, [[Renal Cancer]])

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Contraindications

• Squamous Cell Lung Cancer: due to risk of hemorrhage
• Central Nervous System Metastases: due to risk of hemorrhage

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Pharmacology

• Monoclonal Ab Which Binds To and Inhibits Vascular Endothelial Growth Factor (VEGF)
  • Inhibits tumoral angiogenesis

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Administration

• xxx

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Adverse Effects

Cardiovascular Adverse Effects

• Congestive Heart Failure (see Congestive Heart Failure, [[Congestive Heart Failure]])
  • Epidemiology: mostly when bevacizumab is used in combination with anthracyclines, rasing question of true association
• Hypertension (see Hypertension, [[Hypertension]])

Gastrointestinal Adverse Effects

• Gastrointestinal Perforation (see Intestinal Perforation, [[Intestinal Perforation]])

Hematologic Adverse Effects

• Increased Risk of Thromboembolic Disease (see Hypercoagulable States, [[Hypercoagulable States]])
  • Epidemiology: 2-fold increased risk
  • Physiology: may be due to vascular injury
• Thrombotic Microangiopathic Hemolytic Anemia (see Hemolytic Anemia, [[Hemolytic Anemia]])
  • Microangiopathic Hemolytic Anemia (MAHA)
  • Hypertension
  • Renal Failure

Neurologic Adverse Effects

• Posterior Reversible Encephalopathy Syndrome (PRES) (see Posterior Reversible Encephalopathy Syndrome, [[Posterior Reversible Encephalopathy Syndrome]])

Pulmonary Adverse Effects

• Pulmonary Hemorrhage from Lung Cancer Tumor Necrosis
  • Prognosis: fatalities have been reported

Other Adverse Effects

• Impaired Wound Healing
• Osteonecrosis of the Jaw
• Ovarian Failure

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References

• xxx