Histoplasmosis


Epidemiology

Changing Geography of Infections

Changing Source of Infections

Risk Factors


Etiology

Histoplasma capsulatum infection


Physiology

Routes of Transmission

Incubation Period

Phases of Infection


Diagnosis

Sputum GS/Cult+Sens

Sputum 10% KOH

FOB

Pleural Fluid

Pleural Bx

Transthoracic Needle Aspiration

CXR/Chest CT Patterns

Serology

Histoplasmosis Skin Testing

CBC

ACE Level

Blood Cult+Sens

Bone Marrow Bx

Liver Bx


Clinical Presentations

Pulmonary Manifestations

Asymptomatic Histoplasmosis

Acute Histoplasmosis

CXR/Chest CT Pattern
Clinical
Residual Changes (after healing of primary infiltrate and adenopathy)

Chronic Pulmonary Histoplasmosis

Disseminated Histoplasmosis

Histoplasmoma of UA

Dermatologic Manifestations


Treatment

Treatment of Pleural Effusion

Mild-Moderate Histoplasmosis (Pulmonary, Disseminated)

Severe Histoplasmosis (Pulmonary, Disseminated, Immunocompromised host)

Use of Anti-TNFα Medications in Patients At Risk for Histoplasmosis


References