Myeloproliferative Disease: accounts for up to 50% of hepatic vein thrombosis cases
General Comments: the JAK2 (V617F) mutation is present in 26-59% of hepatic vein thrombosis cases (JAK/STAT pathway plays a critical role in cellular proliferation and cell survival)
Liver has Complex Vascular Supply and High Metabolic Rate: makes it vulnerable to circulatory dysfunction from a variety of etiologies
Congestive Hepatopathy (see Congestive Hepatopathy): passive hepatic congestion, usually attributable to right-sided congestive heart failure (with or without decreased cardiac output
Budd-Chiari Syndrome is Due to Hepatic Vein Obstruction
Obstruction Must Be Due to Predominantly Venous Process (Venous Thrombosis or Phlebitis) and Cannot Be Due to Cardiac Disease, Pericardial Disease, Sinusoidal Obstruction (Hepatic Veno-Occlusive Disease)
Primary Budd-Chiari Syndrome
Obstruction Must Be Due to Predominantly Venous Process (Venous Thrombosis or Phlebitis) and
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