Bleomycin


Indications


Contraindications


Pharmacology

Anti-Neoplastic Mechanisms

Myelosuppression

Bleomycin Pulmonary Toxicity

Metabolism


Administration

Dose Adjustment


Adverse Effects

Allergic/Immunologic Adverse Effects

Anaphylaxis-Like Syndrome (see Anaphylaxis)

Cardiovascular Adverse Effects

Acute Chest Pain During Bleomycin Infusion (see Chest Pain)

Dermatologic Adverse Effects

Skin Toxicity

Gastrointestinal Adverse Effects

Nausea/Vomiting (see Nausea and Vomiting)

Weight Loss

Otolaryngologic Adverse Effects

Stomatitis (see Stomatitis)

Pulmonary Adverse Effects

General Comments

Classic Bleomycin Pneumonitis

Bleomycin-Induced Pulmonary Infiltrates with Eosinophilia-Type Pattern (see Drug-Induced Pulmonary Eosinophilia)

Bleomycin-Induced “Radiation Recall” Phenomenon (see Radiation Therapy)

Bleomycin-Induced Lung Nodules (Cryptogenic Organizing Pneumonia-Type Pattern) (see Cryptogenic Organizing Pneumonia and Lung Nodule or Mass)

Acute Chest Pain During Bleomycin Infusion (see Chest Pain)

Pneumothorax (see Pneumothorax)

Pneumomediastinum (see Pneumomediastinum)

Pulmonary Veno-Occlusive Disease (see Pulmonary Veno-Occlusive Disease)

Rheumatologic Adverse Effects

Scleroderma-Like Syndrome (see Scleroderma)

Other Adverse Effects


References